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Baddman said:
third game????

"We wanted to tell an interactive story over the course of three games," Hudson said. "So your choices don't just affect what's happening in the story, they affect all that's happening in the first game and really start impacting the world you experience in Mass Effect 2. And by Mass Effect 3 you'll see things really diverging and end up in completely different kinds of conclusions to the entire trilogy."

http://xbox360.ign.com/articles/984/984307p1.html

Sorry, I can't find a better interview (I am sure that the developer said "Mass Effect 3 will be affected too")