Game of the Year this year will truely be deserving of whichever game wins it...
BioShock
Halo 3
Ratchet & Clank TOD
The Orange Box
Call of Duty 4
Probably Assassin's Creed
Probably Super Mario Galaxy
Probably Mass Effect
Probably Drake Unchartered
will all be in the running. I wouldn't want to be voting though... I would be switching about 6 times as I like each of those games for very different, but equally compelling reasons.