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It could be (just about) anything, but I would personally bet against a Zelda, Starfox Adventures, or Donkey Kong game with the impending release of New Super Mario Bros. Wii and Super Mario Galaxy 2. I wouldn't be that surprised if Nintendo was going to release a game like Pokemon, Advance/Battalion Wars, Starfox, Diddy-Kong Racing, F-Zero, or Pikmin; and Nintendo could also release a long lost property like Mario Paint or Kid Icarus.