MAFKKA on 23 September 2009
Go for Dead Drops side mission. They give a deeper story behind what is happening.
And like someone said, go all out Good or all out Evil. I thought the Good side was a great way to start when you do your first playthrough, and Evil second because then you've mastered all your powers and you know what to expect, so when the city starts to hate you hand throw rocks and shoots at you, you're better prepared.
