Realistically speaking it is probably possible to port RE5 to the Wii although I'm not sure if you'd want Capcom to take that approach. Generally speaking, Resident Evil games have been fairly simple in terms of interaction (typically scripted) and AI and have thrown most of the systems' resources towards graphics; on top of this they also have some very smart developers who take advantage of the limitations in gameplay to pre-render a large portion of the graphics. This single focus on graphics is why Resident Evil games have been some of the best looking games of every generation. Now, what this means is that to port Resident Evil 5 to the Wii the main thing you need to address the differences between the graphical capabilities of the PS3/XBox 360 and the Wii. In terms of 3D geometry the Wii is not as powerful but this isn't that big of an issue anymore; the jump in the ammount of geometry between the Wii and XBox 360/PS3 isn't that large and most of the additional polygons are acutally used to smooth the mesh. A good developer should be able to scale back the models to an acceptable level. In a very similar way the base texture should be also very simple to convert to use on the Wii. The area I would expect difficulty porting is pixel effects; even though the Wii has an advantage of not supporting high definition, on a per pixel basis the Wii is still much less powerful than the PS3/XBox 360. I expect that every surface in RE5 will probably have a normal map, material effect, and probably other texture effects. On top of this most of the lighting will be handled with per-pixel lighting effects which will be difficult to replicate on the Wii. Ultimately, the game could be ported intact on the Wii but I'm not sure if it would maintain the 'tone' due to some of the changes that would have to be made. It would make far more sense to create a spin-off series, and many of these problems would not have been issues if they designed for the Wii and upgraded to the PS3/XBox 360.