Ugh, that's why I smile when I think about the PC version of Elder Scrolls 4. The trusty console and user mods can help to unbreak or get around certain quests.
One time I picked up an item before I was apparently supposed to pick it up (and therefore trigger the next part of the quest) so now I was stuck with a quest item that couldn't be dropped and a quest I was now stuck in. Good old console commands came through and I was able to force the item to be dropped from my inventory so I could pick it up again and get the quest rolling again.
I was so frustrated by the vampire cure quest. I was legit the first time through and after ALL that hard work the quest broke and I could never complete it. Good old console came through again with my 1000 gold.
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The main LBP levels are so insane. I have no clue how they did certain things and then I'll see some pretty insane stuff in the online too. The dead space levels come to mind right away.







