I could never do the Train level of Goldeneye on 00-Agent... I never understood what I had to do for a while, then when I found out I had to shoot both Ouromov and Xenia without hitting Natalya, I tried it a few times then just gave up.
Majora's Mask is difficult all the way through, but no difficulty spike
F-Zero GX story mode is a beast on the hardest mode, and in fact the 2nd hardest mode (there were 4 weren't there?) And I don't think I even completed the last level even on the easy mode.
The Conduit on the hardest mode is insane, I would say harder than the 3 games I have already mentioned.
Henry on No More Heroes on bitter difficulty is a beast too. In fact I suppose the last 3 bosses of NMH are challenging on any difficulty level, it's just Bad Girl and Jeane you can learn how to dispose of them well enough... wheras Henry you can learn how to avoid his attacks, but you are forced to grind away at him on bitter difficulty (I think it took me 800-900 hits on him, over about an hours fight to beat)
