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There were initially problems aplenty with lack of driver support, but these days you'll be absolutely fine unless you have some really esoteric piece of legacy kit. You won't get the full benefit of a 64 bit processor + a 64 bit OS until more developers start producing 64 bit versions of their programs, but equally you won't be penalised as they'll still run just fine, and 64 bit is the future (man).

Get the 64 bit version of Windows and you won't lose out over the 32 bit version, and you may gain in the future.