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Viruses are slowly dying out. If you get a chance to compare traffic logs on servers, you notice that virus activity has been down significantly between the past of even two years ago and the present.

These days you're guarding less against viruses and more against mal/ad/spy-ware. At this point all you really need is a brain, a browser that limits scripts, and a firewall.

I run Eset NOD32 on my PC but it really only exists for those times when I know I'm pulling a file from an untrustworthy source.