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Regarding the system recommendations for the PC version of RE5, you will want to be playing a gorgeous looking game like this on a decent system with a good VGA card made for gaming.

If you can't be bothered with upgrades on a regular basis, you may as well stick with console gaming; it's a lot less hassle for those who don't actually enjoy buying new parts and building new systems on a regular basis.

Not sure why developers are recommending quad core CPUs at this stage, even though they've been out since 2007. General consensus remains that clock speed for games still matters more on the CPU side. Pretty relevant if you're running stock clock speeds on a quad rated under 3ghz. Of course a Quad OCed to 4ghz won't be running games any slower than a Duo OCed to 4ghz.

I still use an E8400 OCed to 3.9ghz for my game specific PC and it's the HD4870 that's still the bottleneck in terms of seeing higher frame rates at higher resolutions.

The RE5 benchmark runs considerably slower on a stock clock Q6600/9600GT system (32bit) even at 1680x1050 compared to the OC E8400/HD4870 (64bit) at 1920x1080 due to the video card and clock speeds.