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From what I read, it sounds like a mediocre/average series.

http://www.animenewsnetwork.com/review/black-blood-brothers/dvd-1

I'm sure it's not horrible, but I never really dug the whole vampire genre in the first place. http://www.basugasubakuhatsu.com/blog/2006/09/14/black-blood-brothers-anime-first-impressions-preview/

 

Above link has user comments and they seem to be positive. But, those user comments come from extreme spectrums, with low profile anime usually only attracting the positives since they won't suffer from the anti-bandwagon-bandwagon like Cowboy Bebop, Lucky Star, Haruhi, Naruto, and all the other "over hyped" anime will suffer from.