lol it's funny that you placed Uncharted on that list - this is the kind of game that simply copied Tomb Raider and added few Gears of War things here and there. the also Wii Sports should be on this list just like Wii Fit those to games changed everything and thanks to them MS and Sony made their own motion controlers so.
my list would be more like this(excluding handhelds) in no particular order:
LBP,
Gears of War,
Halo 3,
CoD 4,
Mario Kart,
Wii Sports,
Wii Fit,
Bioshock,
Rock Band - more influencial than GH this gen introduced drums, guitar and mic combo,
Saints Row - yes it's one of the most influential games since this was pretty much the first sandbox title this gen(right now we are flooded with those games) that also was the first to have fully customizable character,
MGS4 is a good game but it didn't influenced anything(same goes to Uncharted and Twilight Princess).
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