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LOL, where are Wii Sports, Wii Fit, Nintendogs, Brain Age, and many more?
Let me put together a better list:

MAZEME PROUDLY PRESENTS: THE TOP 10 MOST INFLUENTIAL GAMES OF THE GENERATION!!!

10. Monster Hunter Freedom Unite (PSP)
The best selling PSP Monster Hunter. Monster Hunter revived the PSP in Japan, also thanks to a slowing down DS and very low console sales.

9. Guitar Hero III (Xbox 360, PS3, Wii)
The Guitar Hero that became most well known. Guitar Hero has ever since been a cultural phenomenom.

8. Mario Kart Wii (Wii)
The ultimate Wii bridge game. Actually succesful enough to sell on par with Wii Fit at some times.

7. NEW Super Mario Bros. (DS)
The revival of 2D Mario. Even though the game wasn't as good as, say, SMB3 or SMW, it still went on to sell over 15 million copies. This shows how powerful 2D Mario is.

6. Final Fantasy III (DS)
I believe the first big selling DS RPG. After this, the DS practically became one of the best RPG systems in history, up there with the SNES and the PS2.

5. Nintendogs (DS)
The first big expanded audience game on DS. The ressurection of virtual pets sold around 20 million copies(and is still selling!), and spawned the infamous ''Z'' series of Ubisoft.

4. Brain Age (DS)
The other big DS expanded audience game that became the face of the handheld for many people and spawned many clones in the newborn ''brain gymnastics''-genre.

3. Wii Play (Wii)
The first minigame-compilation on Wii. Nuff said.

2. Wii Fit (Wii)
The Second Coming in many ways. Gave the Wii new impulses, became a cultural phenomenom and is currently selling as if it were a console of its own.

1. Wii Sports (Wii)
Currently the best selling game ever, Wii Sports MADE the Wii. Without Wii Sports, the Wii wouldn't have been this big by far. This game will be to the Wii and its successors what Super Mario Bros. was for the NES and everything that came after.