Full Throttle: Hell on Wheels comes to mind. I loved the first game and I would have loved playing a sequel even if it wasn't a point & click. But without Roy Conrad, I'd rather remember the original as a fond memory unless another voice actor can match his awesomeness.
Another game I was looking forward to was "The Four Horsemen of the Apocalypse". A game that focuses on four playable characters left on Earth after the Rapture and that's a really cool premise I think. It was canned when 3DO went under.
Member #50 of the Sonic Support Squad! :P







