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Resident Evil 5 is an awesome game, but Capcom had to make some changes to make that game accessible to two players of different skill sets. The "puzzles" are stripped down, and the bosses are pretty generic. As a game, I have to say Resident Evil 5 is better. As a Resident Evil game, I have to say I very much prefer Resident Evil 4.

Resident Evil on the Gamecube will forever dominate my memories, though.