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Squilliam said:
If you ignore the WASD buttons as they are the equiv of the left analogue stick you can play many PC shooters with 1-2 buttons. All you need is the fire button and some games require the use button as well.

Not true, because if it were true then lefty's would have a much easier time remapping their keys. 

Take any given FPS on the PC and just try to make a comfortable lefty control scheme.  If you really want to be hardcore don't use the numpad.