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BTW, I think a better metaphore than insects is cancer. If you think of the universe as a living being (full of life) the Fore runners saw the flood as a cancer.

Even if they left the galaxy, the flood would consume all other life in the galaxy and eventually expand wherever they went. And once cancer spreads too far you can't stop it.

So the plan was to take out the cancer in this small area (small being relative, in this case one galaxy).