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I have a quick amendment seeing as I just did the Jefferson Memorial side quests. There is about thirty minutes of content there. About fifteen minutes for each for two quests. They are very modest a few conversation choices, and an easy gun battle. Though you should make it a point to do these quests, and if you can do them before the main quest. Unless the following applies.

WARNING MINOR SPOILER, ACHIEVERS SHOULD PROBABLY READ.

The Holy Water quest costs you the Megaton water beggar. For those intending to manipulate karma, and saves to get those three karma achievements it is probably better to not do this quest. Especially since it is a mere three hundred cap award, and it costs you the most convenient beggar in the game.

For those that are scratching their heads as long as you have pure water to give the beggar he will give you good karma. He is like a karma machine. So if your a bad character get a kill or two from the final level then save. Now all you need to do is restart, from that point for each karma achievement. Bad do nothing, neutral enough water to be neutral, good enough water to be good. Now if you were so foolish as to have actually drank your good water, and want to do this. All you need do is raid the Citadel there is ungodly amounts of pure water in the courtyard.