Mario has only been milked in certain areas. The "Super Mario" games are still excellent, but things like Mario Party, and all the Mario sports games have pretty much run their course. Then again, the new Mario Party games are still fun, they just haven't changed much of anything.
Guitar Hero is about as milked as it can be, but as soon as Rockband 3 gets released with a keyboard, you know GH will have to strike back with a saxophone or something dumb.
Pokemon games don't really change. I had Pokemon Red and I didn't buy another Pokemon game until I got Pearl. It was the same damn game!
Finally, The Sims and their endless expansion packs. I like the way that The Sims 2 was a big step up from the Sims 1, but it was released like 4 years ago, and all we've gotten since then are more add-ons. I hope the Sims 3 does somehing to change the formula a bit.
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