Where are the bashers? Multiple disks? Hah! blu-ray for teh winz...
Mr. Stick has it right, though. Swapping disks isn't an issue unless it is a regular back and forth kind of thing. If it is a 10 hour game with 2.5 hours per disk, I'd be irritated somewhat. If it is a 100 hour game with 25 per, I don't think it matters in the slightest.