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What is funny, is people claiming RE was originally about zombies, it's strayed from it's roots is funny. RE was never about Zombies, it was about developing a biological weapon, to be used against people and to make people into a biological weapon. Sure at first this meant zombies, if you ever actually read the documents found, game per game you would notice. In zero it talks about the origin of the virus. In code veronica they mention an origin point of the leeches. Each RE is just building on top of that, if it changes genre it can't hurt it, because it never was a specific genre, when RE4 came out, it wasn't a new strain, but a whole new idea on bio-weapons, which of course was a plagus. In RE4 they even talk about finding the origin, which is linked to Africa.