As a franchise certainly not. Ultimately depends on sales of RE5 and RE:DC but I expect those to be profitable if not highly profitable.
RE as a horror/Survival game, might be dead though. I can only hope RE and RE0 sell amazingly well on Wii and prompt Capcom to return to more of an atmospheric RE style but that's highly unlikely and we know it. RE6 will probably be like RE5 turned up to 11. *sigh*







