Well, keep in mind that you have to buy GTA4 to play Lost and Damned, am I right?
Also, you would HONESTLY replay the mission on GTA4? I beat it on PS3, and I have not doubt in my mind that I would do the missions all over again. Only point in doing the missions for me was so I can go to all 3 islands and get trophies. After I got them, I have no intention in playing it.
With Killzone 2, I can play all 4 difficulties on campaign just to see how good the AI is and maybe more trophies. Also seeing if I just missed anything interesting. Honestly, most people will play campaign twice if they are interested in Single Player. You have to beat it once to unlock the last one [I think]. Easily, that's 16-20 hours there. Then you have the option to play multi-player which is the core of most people buying the game.
Honestly, what I just said about Killzone 2 applies to all shooters, but the MP in this will be more addictive and fun than others. By the way, I've never been into FPS games until I bought a PS3 and played Resistance. Seeing as this is coming up, I will be sure to pick it up. Also, I'll be planning for Call of Duty: Modern Warfare 2 this year also.