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So many to choose- Tingle, Navi, Waluigi, the horrifically bad voice actor of Altair. But a few are especially annoying.
Ashley Williams (Mass Effect) is the most annoying, shallow and overall bitchiest character ever. She and her pessimistic ass can go to hell.
Still, the worst characters ever are either Yuffie or Cait Sith (FFVII). They are extremely irritating and provide absolutely nothing. At least Barrett, the walking stereotype, is mildly interesting.