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soulsamurai said:
What causes him to age is that he was a clone of big boss, and if you clone a 50 year old, your genes are gonna be that of a 50 year old and aging onward. You're gonna go real fast.

 

Genes don't work like that.  Your basic genetic code should stay the same throughout your life, and it is ultimately cell division that causes things to go wrong after a time (due to cells not dividing correctly, cells mutating, etc.).