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In RE4 you fight a boss that is the little guy inside a giant creature, well the way to kill it first is to shoot it in the eye, I had an automatic weapon and I just held the firing button down, the sound when I hit the eye and the liquid the eye expelled when shot was one of the most pleasant experience shooting at something in videogames, I just enjoyed it too much, the sound was just like if you got your fist into a jar of mayonnaise and the liquid seemed thick and yellow and there was a lot of it....