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flagship said:
-Mass Effect's got the whole greater than light travel and eternal evil that threatens the whole universe (basic story behind several award winning Sci-fi novels (engines of god, fire upon the deep)

-Psychonauts has well psychic powers.

-Chrono Trigger and Chrono Cross play the classic time traveling bit

- The Red Alert and Shadow Hearts series pull the whole parallel alternate universe what if bit.

- Lots of RPGs (Wild Arms1, Lunar 2, Grandia 1) use long lost ancient civilizations of tremendous power.

- Fallout uses the post apocalyptic theory.

That's all pretty generic and not very specific. And you in fallout you are missing a big part of what it's meant to be... my guess is you only played Fallout 3.