Alan Wake(I believe it will reinvigorate the REAL Survival horror genre), Lost Odyssey, MGS4, SMG, and I personally hope that vesperia will become one too. But all I'm absolutely certain of is that it'll be worth a lot of money someday in the future.
GOTY Contestants this year: Dead Space 2, Dark Souls, Tales of Graces f. Everything else can suck it.