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I'd go Bioshock.

Maybe Mario Galaxy.

I don't think a PS3 game can win considering it doesn't have the install base. Which granted shouldn't matter. But it totally will.

I'd guess Bioshock... partially because it interests me more then Galaxy. (It just does. I'll likely own both, but not till next year.)

Partially because of the whole Wii doing the best sales wise but still not getting enough credit with proffesional videogame magazine establishments.