My Predicts:
Halo 4
New Halo game (not FPS) - Peter Jackson project?
GTA5
At least one major PS3 exclusive going multiplat
Forza 3
New Molyneux game
Killer Instinct or Perfect Dark iteration + new ip from RARE and a new DS title.
And most of these titles except for the RARE/Molyneux ip will drop within 12 months time. Also, no Gears related stuff but maybe a hint that EPIC is working on a new MS published ip.
"Man is born free but is everywhere in chains" - Rousseau