I would think Mass Effect II could possibly outsell it, assuming it pulls an Empire Strikes Back/X2 thing and really blows its predecessor away (and it is very possible). But then again, it hasn't been announced for any specific platforms, so who knows if it'll be a console exclusive.
Fable II has sold impressively, though, and could do well with legs. Holiday releases tend to do that do to the fact that so many of us have no possible means to play all of the great games released.








