Bionic commando rearmed on hardest is quite a challenge
Megaman 9 is hard on the beggining, couple playthroughs later and you can finish without dying.
CoDWaW on veteran is just frustratingly broken
R2 on difficult is, well... difficult
Only ones that made me scream though were rearmed and CoD

Flow -"The important is to pwn other ppl"







