1. Mario Kart Wii (unknown total, should be over 300 hours though)
2. LoZ:TP (~184 hours)
3. RE4:Wii (~183 hours)
4. Wii Sports (~108 hours)
5. Endless Ocean (~94 hours)
6. Super Mario Galaxy (~68 hours)
----
Not sure what comes next, as I have played some of them since the last time I updated, but...
BWii and SSX:Blur are both somewhere between 50 and 60 hours, and Excite Truck follows at just short of 40 hours