Good God, there are so many cheat-ass players in here. You're missing the spirit of Fallout here, boys.
I'm playing the game as a pretty weak physical character on Hard difficulty and I don't think the game is very difficult. I even manhandle the Regulators pretty easily now and I just wasted a squad of Talon Company (about 6) with four stimpacks.
The worst are those bloody sentry bots. I hate them. And the Mirelurk Hunters. Bunch of cockgobblers, they are. Deathclaws are a bitch if you don't see them first, too. If you get the drop on them they're not that bad, though.
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