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MMMKAY READ THIS IF YOU DONT WANT TO BE DISAPPOINTED !!!

DO NOT... I REPEAT DO NOT... Finish the main quest first... do the majority of the side quests first... then complete the main quest because i swear to god... if you do the main quest first... the game could very well be ruined for you...

Other Tips: Repair imo is the most important as i definitely use it the most, armor especially can get into disrepair fast after a few good sized brawls and it helps to have high repair to keep it in peak condition...

Small Guns is important but if you get FAR into the game you may (as I do) find yourself using Energy Weps more...
Especially because they are FAR more effective against heavily armored enemies... and also have a higher hit accuracy in terms of spread... god my weapon of choice is DEFINITELY the Plasma Rifle...

Heres a tip, its a glitch not everyone knows... when you get dogmeat (a follower) and another follower... if you kill dogmeat it lets you get another follower of your choice... for instance right now *small spoilers* I have Charon and Fawkes as my followers... Charon is using maxed out T51b power armor... I can literally walk into a room of Enclave soldiers and they will decimate the Enclave while all i have to do is watch and then loot their bodies when the carnage is over... the only bad part of this is you don't get EXP for followers killing your opponents.