Mario 64 should run away with this one for home consoles. The game by which all 3d platform games will be judged.
But as far as overall, Tetris for Game Boy was about the biggest thing to EVER hit gaming. It even made adults want to play handheld games (which was, by many industry experts) thought impossible. No game has identified with so many different people and created such a vast audiance.
Some will try to argue Wii Sports but I will disagree because that game has not exactly opened up the market for buying games at this point. It has swayed a lot of gamers but as of right now, there is no proof that the game is actually broadening the market like Tetris did.
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