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  • Zack and Wiki - best game this gen.
  • Mario Kart Wii - Second only to Zack and Wiki.
  • Super Mario Galaxy - One of the other best games this gen and better than Mario 64.
  • Metroid Prime 3: Corruption - Great shooter that nailed the controls.  Don't worry if you haven't played the previous two.
  • Excite Truck - Pure and simple fun.  I still play this when I need a good 10-15 minute gaming fix.
  • Super Paper Mario - Spectacular writing.
  • Boom Blox - It may just be a physics demo but it's a damn fun physics demo
  • Okami Wii - Only if you didn't play it on the PS2
  • Resident Evil 4 - One of the best games ever only gets better with the PS2 content and better controls
  • Rayman Raving Rabbids (series) - The humor in these game is absolutely brilliant, but you don't need to get all three.  You only need to get one of them.  From what I've heard, if you have a balance board you want the third one.
  • Wii Fit - It's cool and opens you up to a few good games
  • Warioware: Smooth Moves - 12 player multiplayer is some of the most fun I've ever had.  If you have a group of real life friends you must get this game.  If you don't have friends that can come over, don't waste your time with this game.

I don't want to put Zelda on the list because, and I'm sure this is just me, I didn't think it was anything special. 

I also didn't put No More Heroes on the list because while there are amazing things about it, if you have a 360 or PS3 you can get much better open world games.

There are more good games on the Wii, but those are the best ones of each of the genre they're in (across all platforms) and the ones that you can only experience on the Wii that you just need to.