There are a few games I can think of and they have been mentioned such as Godfather, Madden and a couple others. There are more if I looked through their list of games. I think the problem is that many longtime Nintendo fans mostly stick to Nintendo franchises or other big companies big games such as Capcom's Resident Evil or Sega's Sonic. So even traditional hardcore fans might not be experimenting much by going outside the Nintendo lineup.
As much as I can expect quality usually from Nintendo's lineup, I'm sometimes hesitant with other games. Despite that, I've picked up quite a few 3rd party games such as Godfather, Zack and Wiki, Trauma Center Second Opinion, Ghost Squad to name a few. Since I do think that some people feel the same and are hesitant to get games from other publishers and why there are numerous games that haven't or won't hit the million mark that probably should.
I'll come up with something better eventually...
