I think even if it were shovelware I would buy a Futurama game.
Though I'm lukewarm on the actual series I think American Dad could very easily transpose into a game.
I think for my son I would really like Lunar Jim; it has huge potential to be a game (though I doubt it ever will be).
And just going retro for a minute, I might shell out money for a GI Joe game based on the 80s cartoon.