Wii Fit wont be the winner, its too alternative. MKWii and SSBB maybe but sequels arn't unique enough. My pick would be de Blob but its not realistic considering the other massive commercial titles like MGS4.
If i had to guess GTA4 is the most likely candidate
“When we make some new announcement and if there is no positive initial reaction from the market, I try to think of it as a good sign because that can be interpreted as people reacting to something groundbreaking. ...if the employees were always minding themselves to do whatever the market is requiring at any moment, and if they were always focusing on something we can sell right now for the short term, it would be very limiting. We are trying to think outside the box.” - Satoru Iwata - This is why corporate multinationals will never truly understand, or risk doing, what Nintendo does.
