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The Lightning Plasmid is extremely valuable, using it to shock splicers then put a bullet or two in their head.

But there are definitely some Plasmids and Upgrades that i never had any use for. I didn't even need some of the weapons, I rarely used the grenade launcher, crossbow and even chemical thrower. It was mostly all Machine Gun and Shotgun for me.

The Telekinesis Plasmid was tons of fun. I loved grabbing gas tanks and launching them at groups of splicers and watching them go kaboom.

As for Big Daddies, I found the shotgun to be most effective