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Metroid Prime (timeline wise) comes in between Metroid Prime 2 and Super Metroid

The first Mother Brain is destroyed at the original Metroid.

The second Mother Brain is destroyed in Super Metroid.

I am not sure if the final boss of Metroid II (GB) was a Mother Brain or not, cause I never played it but I believe it to be so.



There is many 'Mother Brains' and basically after seeing this I consider that they are Aurora units captured by Space Pirates and given 'evil' 'space pirate' like thoughts and patterns (the trailer talks about Male, Female and different judgements depending on their usage) to make it what we consider a 'Mother Brain'.

Geddit?