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Er... it's exactly what ssj12 said. It's because when 'them' took the samples from Big Boss, he was in his 50's. He was old material.

That's why Solidus looked so old on MGS2, but in his case he aged faster than Liquid and Solid. Also Solid looked like he aged ten years in the two year lapsus between the tanker incident and the plant incident in the same game.