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@Ail

Yesterday I finished the game on Survivor with no Vita-Chambers and it gave me the trophy for Hard with no Vita-Chambers. So yes, all the gold trophies can be earnt in one run.

All I have left for Platinum now is the diaries and the tonics. I plan to rush through on easy with Vita-Chambers for them. My only concern is that I can't find anywhere a list of the locations of the five tonics that are new to the PS3 version. I'm hoping to just stumble upon them.