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If you're referring to comfort alone, it would have to be keyboard + mouse, and then 360, with neither the Dualshock or Wiimote and none of them are particularly ergonomic, though the Dualshock > Wiimote for comfort.

However saying the 360 controller is the 'best' is just stupid, it doesnt even come with a rechargable battery :p and doesn't feature motion control!

However, the G25 should be no. 1, even if it's excluded for just dring games :P