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thekitchensink said:
You haven't even fought a Big Daddy yet--those fights are some of the defining moments of this generation for me!

Also, mucking about with all the insane plasmids you can get later on, and figuring out how to best use them in your current situation, is GREAT fun.

 

And even better than fighting one Big Daddy, is having two of them fight each other.  There's nothing like getting some easy Adam at virtually no risk to yourself.