Just by shear economics, games on the PS3 are currently more likely to fail to profit than any other system.
But that isn't a sure thing by any means. As for picking a certain game....
How about Halo 3?
j/k lol, honestly, I can't think of a game that I would say is most likely not going to turn a profit but thats probably because 3rd parties do their research before sinking cash into a game. The games that won't profit are going to be games that we have never heard of before and might very well never hear of.