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Well, I'm pretty sure you can remap your mouse (as well as getting a mouse that isn't made for the right hand) to fit the other hand as well as using a different area of the keyboard, maybe J,K,L, and I?

Anyway, I guess that's why I played a musical instrument for 7 years while I went through junior high and high school. I'm a right handed person and I write with my right hand, but I can do all the complicated stuff like playing Guitar Hero as well as being able to play with a keyboard and mouse configuration.