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... I'm left handed and I've always used a mouse/analog aiming right handed. Maybe I'm more dexterous than you. I also think the Wiimote is sometimes trashy for left handed play. Not primarily the games like RE4, but for the ones like Mario Party 8, Super Paper Mario, etc, where you have to use the Wiimote sideways. The wrist strap can't go on a left persons hand and be held sideways, and there's no sense putting the strap on your right hand, and then switching back to your left. It's probably not even worth Nintendo's time to make a left handed strap revision for the Wiimote, so I guess I'm stuck throwing my wiimote around :P