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It's entirely possible, I do it all the time on my PS2 because I don't have the guitar, I play in Hard and get mostly 4 stars, my brother plays in expert. There's only one thing that's very difficult to do wth a controler and it's when you have a lot of consecutive notes of the same fret too close, you're bound to miss a lot. Of course the game would be better with a guitar (I'd love to have one), but it isn't any less fun with a controller